accutane effects Anti S1P antibodies reduced the expression and activity of hypoxia inducible factor 1О± HIF 1О±, secretion of the angiogenic factors IL 6, IL 8, vascular endothelial growth factor VEGF, and basic fibroblastic growth factor bFGF and decreased vessel formation in in vitro and in vivo models of ovarian, breast, prostate and lung cancers 95 97